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Hua Xu

Xu Hua, Ph.D., Associate Professor

Xu Hua, Ph.D., Associate Professor, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Deputy director of the Institute of Urology in Tongji Hospital. He has a unique experience in the diagnosis, prevention and treatment of urinary tract cancer. During the postdoctoral period, he won the Top level support (2007) and Privileged support (2008) by China Postdoctoral Science Foundation. As a Principal Investigator, his project was supported by the National Science Foundation for Distinguished Young Scholars of China (2008), and he obtained four General Program supported by the National Science Foundation of China (2009, 2010, 2011, 2013). In particular, he obtained 2011 Hubei Provincial Science and Technology Promotion Award (R5), 2013 National Science and Technology Progress Award (R5) . In recent years, he has published up to 20 articles indexed by SCI with the first author or corresponding author, respectively.


Grant Support:

1. Top level support by HUST (Huazhong University of Science and Technology) Postdoctoral Foundation.

Award total: 15,000

Role: Principal Investigator

2. Top level support by China Postdoctoral Science Foundation (2007) ----The establishment of microRNA profile in transitional epithelial cancer of the bladder. Funding No: 20070410286

Award total: 50,000

Role: Principal Investigator

3. Privileged support by China Postdoctoral Science Foundation (2008) ----The molecular biological mechanism in immune evasion of transitional epithelial cancer of the bladder and epigenetic modification in Fas/FasL system.

Award total: 100,000

Role: Principal Investigator

4. Project supported by the National Science Foundation for Distinguished Young Scholars of China (2008) --- The Research on the Mechanism of WSSV Infection based on Host Cell Apoptosis

Funding No: 308008522

Award total: 239,000

Role: Principal Investigator

5. General Program supported by the National Science Foundation of China (2010)---The Research on the Mechanism of WSSV's Recruitment of Host Protein HSC70 in the Evasion from the Host Immunity.

Funding No: 30972276

Award total: 80,000

Role: Principal Investigator

6. General Program supported by the National Science Foundation of China (2011) ---The Research on the Multiple Functions of HSC70 in WSSV’s Evasion from Host Immunity.

Funding No: 31072238

Award total: 330,000

Role: Principal Investigator

7. General Program supported by the National Science Foundation of China (2012) ---The Research on the Intra-nucleus Assembly Mechanism of WSSV Particles Induced by HSC70.

Funding No: 31172441

Award total: 580,000

Role: Principal Investigator

8. Industry Fund of the Ministry of Health in China (2011) ---The research on the Prevention and Treatment of Major Urological Diseases. (PI: Zhangqun Ye)

Funding No: 201002010

Award total: 3,410,000

Role: Co-Principal Investigator

9. National Major Scientific and Technological Special Project for Significant New Drugs Development (2011) --- The Establishment of Internationalized New Drug Assessment in Clinic and Research Platform of Urogenital Carcinoma. (PI: Zhangqun Ye, Anming Chen)

Funding No: 2012ZX09303018

Award total: 14,906,000

Role: 20%


Current publications:

1.Gan Yu, Weimin Yao, Ji Wang, Xin Ma, Wei Xiao, Heng Li, Hua Xu* LncRNAs Expression Signatures of Renal Clear Cell Carcinoma. Plos ONE. 2012-7-8-e42377.

2.Rui Rui, Jiao Lou, Li Zou, Rong Zhong, Ji Wang, Hua Xu* Excess Body Mass Index and Risk of Liver Cancer: A Nonlinear Dose-Response Meta-Analysis of Prospective Studies. Plos ONE. 2012-7-9-e44522.

3.Li Zou, Rong Zhong, Jiao Lou, Xuzai Lu, Qi Wang, Hua Xu* Replication Study in Chinese Population and Meta-Analysis Supports Association of the 11q23 Locus with Colorectal Cancer. Plos ONE. 2012-7-9-e45461.

4.Xiao W, Wang J, Li H, Guan W, Xia D, Yu G, Xiao H, Lang B, Ma X, Liu J, Zhang X, Ye Z, Xu H*. Fibulin-1 is down-regulated through promoter hypermethylation and suppresses tumor progression in renal cell carcinoma. J Urol. 2013 Jul;190(1):291-301.

5.Heng Li, Ji Wang, Wei Xiao, Ding Xia, Bin Lang, Gan Yu, Xiaolin Guo, Wei Guan, Zhihua Wang, Zhiquan Hu, Jihong Liu, Zhangqun Ye, Hua Xu* Epigenetic alterations of Krüppel-like factor 4 and its tumor suppressor function in renal cell carcinoma. Carcinogenesis. 2013 Oct;34(10):2262-70.

6.Lei Chang, Runlin Shi, Tao Yang, Fan Li, Guohao Li, Yonglian Guo, Bin Lang, Weimin Yang, Qianyuan Zhuang and Hua Xu* Restoration of LRIG1 suppresses bladder cancer 3 cell growth by directly targeting EGFR activity  Journal of Experimental & Clinical Cancer Research. 2013 Dec 8;32(1):101.

7.Lei Chang, Wei Xiao, Heng Li, Yang Yang, Ding Xia, Gan Yu, Xiaolin Guo, Wei Guan, Zhiquan Hu, Hua Xu*, Qianyuan Zhuang, Zhangqun Ye. PA-MSHA inhibits EGFR signaling pathway activation and induces apoptosis in bladder cancer cells in vitro and in vivo.  Urologic Oncology. 2014 Jan;32(1):36.e11-8.

8.Heng Li, Ji Wang, Wei Xiao, Ding Xia, Bin Lang, Tao Wang, Xiaolin Guo, Zhiquan Hu, Zhangqun Ye, Hua Xu* Epigenetic inactivation of Krüppel-like factor 4 is associated with urothelial cancer progression and recurrence. J Urol. 2014 Feb;191(2):493-501.

9.Tang K, Xu Z, Xia D, Ma X, Guo X, Guan W, Hu Z, Zhang X, Ye Z, Xu H*. Early outcomes of thulium laser versus transurethral resection of the prostate for treating benign prostate hyperplasia: a systematic review and meta-analysis of comparative studies. J Endourol. 2014 Jan;28(1):65-72.

10.Heng Li†, Gan Yu†, Runlin Shi, Bin Lang, Xianguo Chen, Ding Xia, Haibing Xiao, Xiaolin Guo, Wei Guan, Zhangqun Ye, Wei Xiao and Hua Xu* Cisplatin-induced epigenetic activation of miR-34a 3 sensitizes bladder cancer cells to chemotherapy. Molecular Cancer. 2014 Jan 15;13(1):8.

11. Haibing Xiao, Heng Li, Gan Yu, Wei Xiao, Junhui Hu, Kun Tang, Jin Zeng, Wei He, Guohua Zeng, Zhangqun Ye, Hua Xu*. MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer. Oncology Reports. 2014 31: 1832-1838.


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