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Zhong Chen

Zhong Chen
Nationality
China
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Description

PROFESSIONAL SERVUCES:

secretary-general of the Marco Polo Association of Urology(MPAU),

secretary of Chinese Urological Association

deputy director of International Exchange Committee of Chinese Urological Association

member of the National Cooperative Group of The Diagnosis And Treatment Of Renal Staghorn Calculi

member of  Endourological group of Hubei  Urological Association

editor of “Urologia”

deputy chief editor of “Journal of Contemporary Urologic and Reproductive Oncology”

editor of “Chinese Journal of Endourology(Electronic Version”

ub-editor of “Journal of Clinical Department of Urology”.

 

EDUCATION:

2005.10-2006.10  Postdoctor, Department of Urology,University of California San Francisco

2001.10-2002.3  Fellow, the Postgraduate Specialization School of Urology, Institution Urology, University of Palermo, Palermo, Italy

1994.9-1999.6   Ph.D. candidate (D.Med.Sci.in China), Department of Molecular Biology, Research Center of Experimented Medicine, Tongji Medical University & Department of Urology, Tongji Hospital, Wuhan, China

1986.9-1991.6         M.D. (B.Med.Sci.in China), Tongji Medical University, Wuhan, China

 

RESEARCH EXPERIENCE:

2014.1-2018.12   To study “Mechanism and effects study of targeted therapy with miRNA-activated p21 gene expression in bladder cancer” (Given support by The program of science and technology committee in China(No: 81372759)

2009.9-2011.12   To study “Development and application nanoparticle drug to cross the blood - urine barrier”

2009.1-2011.12   To study “the RNAa mechanism for dsRNA to activate p21 gene in bladder cancer” (Given support by The program of science and technology committee in China(No: 30873018)

2002.4-2006.12   To study “the diagnosis and treatment for low urinary function disease”

2003.9-2005.9    To study “The gene theraphy research for bladder cancer with recombinant 
fibronectin polypeptide CH50”(Given support by The program of science and technology committee in Wuhan(No: 20036004056) & The research fund for young doctors in Tongji hospital(2003)

1999.9-2001.9    To study “The multidrug resistance mechanism of Multidrug Resistance Associated Protein and Glutathion S-Transferase-π in Bladder Transitional Cell Carcinoma” (Given support by The program of science and technology committee in Hubei(No: 99J124)

1995.9-1999.6    To study “The correlation study in the mechanism and reversion of multidrug resistance of human superficial bladder cancer”

 

PROFESSIONAL EXPERIENCE

2010.11-today    Professor, Department of Urology, Tongji Hospital, Wuhan, China

2002, 4-2010.10      Associate Professor, Department of Urology, Tongji Hospital, Wuhan, China

1999.7-2001,9     Assistant Professor, Department of Urology, Tongji Hospital, Wuhan, China

1991,7-1994,8     Resident Surgeon, Department of Surgery, Tongji Hospital, Tongji Medical University, Wuhan, China. Full-time clinical work in Surgery

 

 

PUBLICATIONS ( chronological) :

Original Articles(first author or Corresponding author):

1.      Chen Zhong, Li Jiagui, Yang Yejin, Zhou Huomin. An analysis of toxicity of chemotherapy on bladder cancer cell lines BIU-87 in Vitro by MTT method. Chinese J of Exp. Surgery. 1997, 14(sul.),163-164

2.      Chen Zhong, Li Jiagui, Yang Yejin, Zhou Huomin. A study of the effects of combination chemotherapy on bladder cancer cell lines BIU-87 in Vitro. Acta Universitatis Medicinae Tongji, 1997,26(5),378-380

3.      Chen Zhong, Li Jiagui, Yang Yejin, Zhou Huomin. Effects of combination of interferon with chemotherapy on bladder cancer cell lines BIU-87. J of Clinical Urology, 1998, 13(3), 135-137

4.      Chen Zhong, Zhang Yongshang, Li Jiagui. Expression of multidrug-associated protein(MRP) and P-glycoprotein in bladder cancer. Chinese J of Urology , 1998, 19(7), 394-396

5.      Chen Zhong, Zhang Yongshang, Li Jiagui, Zhang Yongxin. Induction of drug-resistance and p53bcl-2、P-glycoprotein proteins expression by adriamycin or etoposide in human bladder cell lines. Chinese J of Urology , 1998, 19(12),707-709

6.      Chen Zhong, Zhang Yongshang, Li Jiagui, Zhanh Yongxing. Establishment and multidrug resistance analysis of BIU-87/A,BIU-87/V of human bladder cancer cell lines. Acta Universitatis Medicinae Tongji,1999, 14(1),68-70

7.      Chen Zhong, Zhang Yongshang, Li Jiagui, Yang Yejin, Chen gan. Expression of multidrug-associated resistance protein and P-glycoprotein in human bladder cancer multidrug-resistance lines. National Medical J of China. 1999, 79(4),307-308

8.      Chen ZhongZhang yongxing, Zhong Xu,Du Guanghui, Yang Weimin, Hu Ziquan, Li Jiagui, Zhang Yongshang. Expression of multidrug-associated protein(MRP), P-glycoprotein, P53 and Bcl-2 proteins in bladder cancer. J of Tongji Medical University (English). 2001,21(1),63-65

9.      Chen Zhong, Ye Zhangqun, Du guanghui, Liao Limin, Cai Dan, Ma Yangzhi, Zhang Xu, Liu Jihong, Yang Weimin. A clinical observation for sacral neuromodulation in the treatment of dysfunction of micturition. J of Clinical Urology, 2001,16(9), 401-403

10.    Chen Zhong, Zhang Xu, Song Xiaodong, Wang Shaogang, Zhu Qingguo, Ma Xin, Ye Zhongqun. Lparoscopy retroperitoneal ureterlithotomy of(report of 10 cases). Journal of Modern Urology. 2002, 7(1), 14-15

11.    Chen Zhong, Yang Weimin, Zhang Xu, Hu Qing. The relationship between p53 mutation in drug-resistance lines of bladder cancer and chromosome aberration. Chin J Exp Surg. 2002, 19(2), 171-172

12.    Chen Zhong, Yang Weimin, Du Guanghui, Ye zhangqun, Zeng Xiaoyong, Yang Yejing. A study of the effects of combination chemotherapy on bladder cancer cell  BIU-87 and its multidrug resistance lines in vitro. Journal of Huazhong University of Science and Technology·Health Sciences. 2002,31(3),301-303

13.    Chen Zhong, Li Giagui, Yang Weimin, Zhang Yongshang, Zhang Yongxing, Ye Zhangqun, Du Guanghui, Wang Shaogan. Expression of heat shock protein70, P53 and P-glycoprotein proteins in bladder cancer. J of Clinical Urology, 2002, 17(7), 352-354

14.    Chen Zhong, Ye Zhangqun, Li Giagui, Cai Dan, Zhang Huiping, Yuan Xiaoyi, Du Guanghui. The clinic characteristics and analysis of spina bifida occulta. J of Clinical Urology, 2004, 19(5), 278-279

15.    Chen Zhong, Chen Ligong, Ye Zhangqun, Zhang Xu, Du Guanghui, Cai Dan, Zhang Huiping. Survey on the Prevalence of Incontinence in Wuhan City. Chinese J of Urology , 2004, 25(9),590-591

16.    CHEN Zhong ,YE Zhangqun, LIAO Limin, DU Guanghui, CAI Dan, YUAN Xiaoyi, ZHANG Huiping. A clinical effects of sacral never stimulation in treatment of patients with neurogenic bladder. Chin J PhysMed Rehabil, 2005, 27(6),332-334

17.    CHEN Zhong, LI Jiagui, YE Zhangqun, YANG Weimin, ZHANG Xu, ZENG Xiaoyong .Clinical Study of Sequential Intravesical Instillations for the Prevention of Bladder Cancer Recurrence after Surgical Management. Res of Tumor Treatment. 2005, 32(2), 108-110

18.    CHEN Zhong, YE Zhangqun, YANG Weimin, DU Guanghui, CHEN Zhiqiang, CAI Dan, YUAN Xiaoyi, XIA Ding, LIU Zhengqing. Complications and management of tension-free vaginal tape surgery. Journal of Clinical Urology. 2005,20(11),658-660

19.    CHEN Zhong, YE Zhang-qun, LIAO Li-min, DU Guang-hui, CAI Dan, YUAN Xiao-yi, ZHANG Hui-ping. A clinical effects of sacral never stimulation in treatment of patients with neurogenic bladder. Chinese Journal of Physical Medicine and Rehabilitation. 2005,27(6),332-334

20.    CHEN Zhong; YE Zhang-qun, YANG Wei-min, CAI Dan, DU Guang-hui, CHEN Zhi-qiang, YUAN Xiao-yi, XIA Ding, LIU Zheng-qing. A prospective study of comparison between tension-free vaginal tape and transobturator inside-outtension-free urethral suspension for the surgical treatment of female stress urinary incontinence. Chinese Journal of Urology, 2006,27(5),321-323

21.    Zhong Chen, Robert F. Place, Zhe-Jun Jia, Deepa Pookot, Rajvir Dahiya and Long-Cheng Li. Antitumor effect of dsRNA-induced p21WAF1/CIP gene activation in human bladder cancer cells. Mol Cancer Ther 2008;7(3):698–703

22.    Hu Jia, Chen Zhong, Wujia, Zhang Yong, Yuan Xiaoyi, Chen Yuan, Du Guanghui, Yang Weimin, Ye Zhangqun. The short-term results of T-consling suspension in treating female stress urinary incontinence. Chin J Urol,33(4),290-292

23.    Hu J, Chen Z*, Xia D, Wu J, Xu H, Ye ZQ*. Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation. Biochem J, 2012,447(3):407-416.SCI IF=4.8972013)

24.    Hu Jia, Chen Zhong*, Wu Jia, Zhang Yong, Xu Hua, Yang Weimin, Ye Zhangqun. Up-regulation of tumor suppressor gene p21WAP1/CIP1 in human cells by small double strand RNA. Acta Med Univ Sci Technol Huazhong, 2012,41(6),660-664

25.    Hu Jia, Chen Zhong, Wu Jia, Zhang Yong, Wang Ji, Guo Xiaolin, Xu Hua, Li Longcheng, Yang Weimin, Ye Zhangqun.Study of saran-directed transcriptional activation of p21WAP1/CIP1expression in human baldder cancer. J Contemp Urol Reprod Oncol, 2012,4(3),165-169

26.    Hu Jia, Chen Zhong, Gong Hua, Wu Jia, Zhang Yong, Wang Ji, Xu Hua, Li Longcheng, Yang Weimin, Ye Zhangqun. Comtruction of p2l saRNA enkaryotic expression vector and identmcation of its function in urinary cancer cells. Chin J Exp Surg, 2012,29(6),1000-1002

27.    Zhang Yong, Chen Zhong, Yang Weimin, Ye Zhangqun. Expression and significance of Livin and HIF-1α protein in carcinoma of urinary bladder. J Clin Urology.2013,28(4),268-270

 

Review Articles:

1.      Chen Zhong, Li Jiagui. The foundation study of intravesical chemotherapy with mitomycin C. Foreign Medical Sciences(Urology),1996,16(1),9-11

2.      Chen Zhong, Zhang Yongshang. The new research works for multidrug-associated protein(MRP). Foreign Medical Sciences(Urology), 1997, 17(1), 3-7

3.      Chen Zhong, Li Jiagui. The side effect for intravesical chemotherapy with mitomycin C. J of Clinical Urology, 1999,14(2),86-88

4.      Chen Zhong, Ye Zhangqun. The manufacture and use of the artificial urinary sphincter. Foreign Medical Sciences(Urology),1999,19(2),60-63

5.      Chen Zhong, Zhang Yongshang,. Apoptosis mechanism in multidrug resistance.

6.      Chen Zhong, Yang Weimin. The relation of Indinavir and urolithiasis. Foreign Medical Sciences(Urology),2002,22(3),185-186

7.      CHEN Zhong. Rehabilitation for neurogenic bladder and urethra dysfunction. Chinese Journal of Physical Medicine and Rehabilitation. 2008,30(3),213-215

8.      CHEN Zhong, LI Longcheng. RNAa and tumor. Journal of Contemporary Urologic and Reproductive Oncology.2009,1(1),1-3

9.      CHEN Zhong, LI Longcheng. research advance of RNAa. Journal of Contemporary Urologic and Reproductive Oncology.2012,4(2),65-68

 

Published book:

As the first editor in chief, published a book “Neurogenic Bladder”. 2009,Beijing, People's Health Publisher.

 

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