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Chew, Ben Hall

Nationality
Canada
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Description

 

INSTITUTION AND LOCATION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

Queen’s University at Kingston, ON

BSc(H)

05/1992

Life Sciences

Queen’s University at Kingston, ON

MSc

05/1994

Master’s of Neuroscience

University of British Columbia

MD

04/1998

Undergraduate Medicine

University of Toronto

FRCSC

05/2003

Urology Residency

University of Western Ontario

Fellowship

06/2006

Endourology and Laparoscopy

 

Personal Statement

The goal of my research is to improve patient care in Endourology—particularly those suffering from kidney stone disease. My areas of research encompass 2 main areas: the design and use of biomaterials in ureteral stents which typically cause so much pain and discomfort to patients and the other area is in intestinal metabolism of oxalate and calcium as they pertain to kidney stone disease.  I have been involved in designing a biodegradable ureteral stent that will degrade over 2 to 3 weeks after implantation. I am a consultant to stent companies and considered a key opinion leader in this field of trying to eliminate symptoms and infectious problems due to biofilms. My past contributions include working on the first 2 drug-eluting ureteral stents to eliminate infection and symptoms.  From this research, I have won Best Abstract Prizes at the AUA and World Congress of Endourology. The other area of oxalate research also garnered a Best Abstract Prize at the AUA for Stone Disease in 2005 as I continue to search for a therapeutic target to prevent patients from getting further kidney stones. I have an interest in education and am an original member of the Stone Institute which is a global teaching initiative in urolithiasis. I am the current Chair of Research for the Endourology Society in charge of furthering international collaborations and improving research in the field of endourology.  I am a co-founder the Endourologic Disease Group for Excellence (EDGE: www.endoedge.net) which is a group of 13 researchers from 12 institutions collaborating to perform high quality research.  We have publications answering important questions in endourology. Other research consortiums include the Wisconsin Quality of Life Research Consortium run by Dr. Kristin Penniston and Dr. Stephen Nakada. My goal is to improve the quality of life for all patients with kidney stones and further our understanding of the pathophysiology of stone disease.

 

Positions and Honors

Positions and Employment

2003-2006  Fellow, Division of Urology, University of Western Ontario, Canada (Supervisor: John Denstedt)

2006-2013  Assistant Professor of Urologic Sciences, University of British Columbia, Vancouver, Canada

2013-Present  Associate Professor of Urologic Sciences, University of British Columbia, Vancouver, Canada

 

Professional Memberships

1998-  Member, Canadian Urological Association

1999-  Member, American Urological Association

1998-  Member, Society of Endourology

 

Other Experience and Professional Memberships

2006-  Consultant:  Boston Scientific Corporation, Cook Medical, Percutaneous Systems, Valera Medical, Poly-Med Inc.,

2007-  Journal reviewer for: Journal of Urology, Urology, Journal of Endourology, Cochrane Database Reviews, Clinical Nephrology, British Journal of Urology International (BJUI), Expert Reviews (Medical Devices), Nature Reviews Urology, Canadian Journal of Urology, Urological Research, Therapeutic Advances in Urology

2009-2013  Chair, Patient Information Committee, Canadian Urological Association,

2010-  Chairman, Organizer, Northwest Urologic Society Annual Meeting

2011-  Society of Endourology, Website Committee

2011-14  Scientific Program Committee (Stones and Laparoscopy), Western Section AUA Annual meeting.

2013-2014  Chair, Young Endourologists’ Forum, Endourology Society

2011-  NIH Peer Review Committee: Project Program Grant, ad hoc reviewer

2011-  General Chairman, Western Section American Urological Association Annual Meeting

2013-  The Stone Institute: developing curriculum, videos, slide content for international courses on stone disease. Approved course by the Endourology Society. 

2014-  Consultant: Bard medical, Olympus Medical, ADVA-TEC Inc.

2013-2017  President, Canadian Endourology Group (CEG), Canadian Urologic Association

2012-2016  Chair, Continuing Professional Development Committee, Canadian Urological Association

2015-  Peer reviewer, AUA Surgical Management of Kidney Stones Guidelines 2015. 

2016-  Consultant: Auris Surgical Robotics

2016-  American Board of Urology, American Urology Association Study Guide Question Developer 2016

2017-  Chair of Research, Endourology Society.

 

Honors

2005  Best Abstract Prize (Stone Disease), Annual American Urological Association Meeting

2005  Best Scientific Paper, 23rd World Congress of Endourology,

2008  Best Abstract Prize (Stone Disease), Annual American Urological Association Meeting

2007-2013  Michael Smith Foundation for Health Research Salary Award

2008  UBC Distinguished Achievement Award for Excellence in Clinical or Applied Research

2008  2nd Place, Society for Infection and Inflammation in Urology New Investigator Competition

2009  Best Endourology Paper, World Congress of Endourology Annual Meeting

2010  Best Research Paper, World Congress of Endourology Annual Meeting

2011  Best Innovative paper, World Congress of Endourology Annual Meeting

2011  European Association of Urology-Canadian Urology Association Exchange Scholar

2012  Postgraduate Teacher of the Year, Department of Urologic Sciences, UBC

2013  Undergraduate Teacher of the Year, Department of Urologic Sciences, UBC

2017  Co-President, World Congress of Endourology, September, Vancouver, BC

 

31 selected publications from 78 Pubmed peer-reviewed publications

These articles involve drug eluting ureteral stents: pre-clinical and bench testing of their antimicrobial activity (Triclosan eluting ureteral stents) and anti-inflammatory effects (ketorolac eluting ureteral stents).

1. Cadieux PA*, Chew BH*, Knudsen BE, DeJong K, Rowe E, Reid G, Denstedt JD. Triclosan Loaded Ureteral Stents Reduce Proteus mirabilis 296 Infection in a Rabbit UTI Model, Journal of Urology, 2006;175:2331-2335. (*equally contributing authors). PMID 16697868

2. Chew BH, Cadieux PA, Reid G, Denstedt JD. In Vitro Activity of Triclosan Loaded Ureteral Stents Against Common Bacterial Uropathogens. J Endourology, 2006, 20(11):949-958. PMID 17144870

3. Chew BH, Davoudi H, Li J, Denstedt JD. An in vivo porcine evaluation of the safety, bioavailability, and tissue penetration of a ketorolac drug-eluting ureteral stent designed to improve comfort. J Endourol. 2010 Jun;24(6):1023-9.PMID: 20367085

 

These articles relate to the biodegradable stent that I have been involved with since the inception and design of this stent. This has just received Health Canada approval and clinical trials will commence 2018.

4. Hadaschik BA, Paterson RF, Fazli L, Clinkscales KW, Shalaby SW, Chew BH.

J Urol. 2008 Sep;180(3):1161-6. PMID: 18639278

5. Chew BH, Lange D, Paterson RF, Hendlin K, Monga M, Clinkscales KW, Shalaby SW, Hadaschik BA. Next generation biodegradable ureteral stent in a yucatan pig model. J Urol. 2010 Feb;183(2):765-71. PMID: 20022028

6. Chew BH, Paterson RF, Clinkscales KW, Levine BS, Shalaby SW, Lange D. In vivo evaluation of the third generation biodegradable stent: a novel approach to avoiding the forgotten stent syndrome. J Urol. 2013 Feb;189(2):719-25. PMID: 22982432

 

Techniques in Stone Fragmentation and New Instruments

7. Humphreys MR, Shah OD, Monga M, Chang YH, Krambeck AE, Sur RL, Miller NL, Knudsen BE, Eisner BH, Matlaga BR, Chew BH. Dusting versus basketing during ureteroscopy - Which technique is more efficacious? A prospective multi-center trial from the EDGE Research Consortium. J Urol. 2017 Dec 15. [Epub ahead of print] PMID: 29253579 (*Top 10 paper of the year)

8. Chew BH, Matteliano AA, de Los Reyes T, Lipkin ME, Paterson RF, Lange D. Benchtop and Initial Clinical Evaluation of the ShockPulse Stone Eliminator in Percutaneous Nephrolithotomy. J Endourol. 2017 Feb;31(2):191-197. doi: 10.1089/end.2016.0664. Epub 2017 Jan 6.PMID: 27863458

9. Scotland KB, Kroczak T, Pace KT, Chew BH. 1.Stone technology: intracorporeal lithotripters. World J Urol. 2017 Jun 12. doi: 10.1007/s00345-017-2057-x. [Epub ahead of print] PMID: 28608192

10. York NE, Borofsky MS, Chew BH, Dauw CA, Paterson RF, Denstedt JD, Razvi H, Nadler RB, Humphreys MR, Preminger GM, Nakada SY, Krambeck AE, Miller NL, Terry C, Rawlings LD, Lingeman JE. Randomized Controlled Trial Comparing Three Different Modalities of Lithotrites for Intracorporeal Lithotripsy in Percutaneous Nephrolithotomy. J Endourol. 2017 Nov;31(11):1145-1151. doi: 10.1089/end.2017.0436. Epub 2017 Nov 3. PMID: 28859485

 

Biofilms and stent research:

11. Chew BH, Rebullar KA, Harriman D, McDougall E, Paterson RF, Lange D.  Percuflex Helical Ureteral Stents Significantly Reduce Patient Analgesic Requirements Compared to Control Stents. J Endourol. 2017 Dec;31(12):1321-1325. doi: 10.1089/end.2017.0349. Epub 2017 Nov 20. PMID: 29048209

12. Elwood CN, Lo J, Chou E, Crowe A, Arsovska O, Adomat H, Miyaoka R, Tomlinson-Guns E, Monga M, Chew BH, Lange D. Understanding urinary conditioning film components on ureteral stents: profiling protein components and evaluating their role in bacterial colonization. Biofouling. 2013;29(9):1115-22. PMID: 24047458

13. Gao G, Lange D, Hilpert K, Kindrachuk J, Zou Y, Cheng JT, Kazemzadeh-Narbat M, Yu K, Wang R, Straus SK, Brooks DE, Chew BH, Hancock RE, Kizhakkedathu JN. The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides. Biomaterials. 2011 Jun;32(16):3899-909. PMID: 21377727

 

Stent and metabolic factors in kidney stone disease:

14. Penniston KL, Antonelli JA, Viprakasit DP, Averch TD, Sivalingam S, Sur RL, Pais VM Jr, Chew BH, Bird VG, Nakada SY. Validation and Reliability of the Wisconsin Stone Quality of Life Questionnaire. J Urol. 2017 May;197(5):1280-1288. doi: 10.1016/j.juro.2016.11.097. Epub 2016 Nov 23. PMID: 27889419

 

Translational Research:

15. Janssen C, Buttyan R, Seow CY, Jäger W, Solomon D, Fazli L, Chew BH, Lange D. A Role for the Hedgehog Effector Gli1 in Mediating Stent-induced Ureteral Smooth Muscle Dysfunction and Aperistalsis.

Urology. 2017 Jun;104:242.e1-242.e8. doi: 10.1016/j.urology.2017.01.029. Epub 2017 Feb 8.PMID: 28188758

16. Chew BH, Brotherhood HL, Sur RL, Wang AQ, Knudsen BE, Yong C, Marien T, Miller NL, Krambeck AE, Charchenko C, Humphreys MR. Natural History, Complications and Re-Intervention Rates of Asymptomatic Residual Stone Fragments after Ureteroscopy: a Report from the EDGE Research Consortium. J Urol. 2016 Apr;195(4P1):982-6. PMID: 26585680

17. Chew BH, Flannigan R, Kurtz M, Gershman B, Arsovska O, Paterson RF, Eisner BH, Lange D.

A Single Dose of Intraoperative Antibiotics Is Sufficient to Prevent Urinary Tract Infection During Ureteroscopy. J Endourol. 2016 Jan;30(1):63-8. PMID: 26413885

D.Ongoing Research Support

Collaborative Health Research Project (NSERC/CIHR) 2018 - 2021

Title: Intelligent Ureteral Stent System for Prevention of Renal Damage

Funding Competitive?: Yes

Co-applicants : Dirk Lange;

Role: Co Principal Investigator

Other Co-investigators: Tenichi Takahata; Jay Kizhakkedathu, hahriar Mirabassi

Total Funding:  $651,291 (NSERC= Natural Sciences Engineering Research Council of Canada, CIHR= Canadian Institutes of Health Research)

 

Collaborative Health Research Project (NSERC/CIHR) 2016 - 2019

Title: Universal Antibiofilm Coating Solutions for Ureteral Stents

Funding Competitive?: Yes

Co-applicants : Dirk Lange; Jay Kizhakkedathu;

Role: Co-investigator

Other Co-investigators: Robert Hancock; Suzanna Straus

Total Funding:  $826,005 (NSERC= Natural Sciences Engineering Research Council of Canada, CIHR= Canadian Institutes of Health Research)

 

Canadian Institutes of Health Research (CIHR)2016-2018

Title:Novel one-step approach to a universal anti-adhesion coating to prevent catheter-associated urinary tract infections

Funding Sources:

Funding Competitive?: Yes

Role: Co-investigator

Co-applicants: Dirk Lange; Jay Kizhakkedathu

Total Funding: $187,302

 

Boston Scientific Global Investigator Sponsored Research (ISR) program2016/11 - 2017/12

Title: Evaluation of a single-use digital ureteroscope versus a re-usable digital ureteroscope,

Project Description: This is a randomized trial to test the effectiveness of the new LithoVue

(Boston Scientific) single use digital chip ureteroscope compared to a reusable (Olympus

URF-V2) digital ureteroscope in the treatment of kidney stones.

Funding Competitive?: Yes

Role: Principal applicant

Co-applicants: Dr. Bodo Knudsen, Dr. Mitchell Humphreys

Total Funding: $257,000 (United States dollar)

 

Boston Scientific Global Investigator Sponsored Research (ISR) program2013-2015

Title: Examining the Underlying Factors that Cause Ureteral Stent Discoloration in Japanese and Canadian Ureteral Stents

Operating Grant: to collect stents from Canada and Japan and to determine the biofilm and surface reactions that cause them to discolor, attract bacteria or encrust.

Role: PI, Co-Investigator: Dirk Lange

Amount: $147,893

 

Boston Scientific Global Investigator Sponsored Research (ISR) program2013-2015

Title: A Prospective Multicenter Clinical Trial to Evaluate the Comfort of the Percuflex Helical Ureteral Stent

Operating Grant: to perform a clinical trial

Role: PI, Co-Investigator: Ryan Paterson

Amount: $147,893

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